Results 1 to 6 of 6

Thread: Study links 'Body Clock' to Sudden Cardiac Death

  1. #1
    Super Moderator cougarnurse's Avatar
    Join Date
    Oct 2006
    Location
    Parked in front of the computer when I am not working
    Posts
    12,327

    Study links 'Body Clock' to Sudden Cardiac Death

    Interesting: http://health.yahoo.net/news/s/hsn/s...-cardiac-death

    The first molecular evidence linking circadian rhythms -- the "body clock" -- to sudden cardiac death could lead to new methods of diagnosis and therapy to treat or prevent the fatal heart problem, a new study suggests.
    Abnormal heart rhythms called ventricular arrhythmias are the most common cause of sudden cardiac death, which is the primary cause of death from heart disease. Experts have long noticed that ventricular arrhythmias occur most often in the morning waking hours, with a smaller peak in the evening hours.

    Despite knowing about this increased risk in the morning and evening, scientists haven't been able to pinpoint the molecular basis for these daily patterns. This study in the March 1 issue of the journal Nature may provide new insight.

    The researchers found that a genetic factor called Kruppel-like factor 15 (KLF15) connects the body's natural circadian rhythm to, and regulates, the heart's electrical activity.

    Too little or too much KLF15 causes a loss or disruption in the heart's electrical cycle and greatly increases the risk of arrhythmias, according to the study. For example, patients with heart failure lack KLF15 while too much KLF15 causes electrocardiography changes such as those that occur in patients with a genetic heart rhythm disorder called Brugada syndrome.

    The findings could reduce the number of cases of sudden cardiac death. For example, medications that increase KLF15 could be given to heart failure patients, particularly during the times of day when sudden cardiac death is more likely to occur.

    "Our study identifies a hitherto unknown mechanism for electrical instability in the heart. It provides insights into day and night variation in arrhythmia susceptibility that has been known for many years," study author Dr. Darwin Jeyaraj, an assistant professor of medicine at Case Western Reserve University School of Medicine and a cardiologist at Harrington Heart & Vascular Institute at University Hospitals Case Medical Center, said in a university news release.

    About 325,000 people in the United States suffer sudden cardiac death each year.

    More information

    The U.S. National Heart, Lung and Blood Institute has more about sudden cardiac arrest/death .

  2. #2
    Junior Member
    Join Date
    Dec 2012
    Posts
    22
    I just encountered this term "Kruppel-like factor 15 (KLF15)"...only in this forum!Thanks for an additional knowledge today!

  3. #3
    Super Moderator cougarnurse's Avatar
    Join Date
    Oct 2006
    Location
    Parked in front of the computer when I am not working
    Posts
    12,327
    Wonder if any of your co-workers have heard of it?

  4. #4
    Junior Member
    Join Date
    Dec 2012
    Posts
    22
    hmm...i'm not really sure!Well I could actually ask them

  5. #5
    Moderator
    Join Date
    Jun 2011
    Posts
    276
    Other than having someone give an Amiodarone bolus one hour before waking, I'm not sure what else can be done to address this concern. Perhaps endogenous catecholamine release has something to do with triggering tachy arrythmias in these predisposed individuals and biofeedback or relaxation-response conditioning could be effective. It's been useful for people who experience Printzmetal Angina. Regardless, I now have some evidence to support the notion that getting up in the morning could be dangerous to my health...

  6. #6
    Super Moderator cougarnurse's Avatar
    Join Date
    Oct 2006
    Location
    Parked in front of the computer when I am not working
    Posts
    12,327
    Or those of us 'allergic' to morning?

Similar Threads

  1. Study links 'Body Clock' to Sudden Cardiac Death
    By cougarnurse in forum Nursing News
    Replies: 0
    Last Post: 02-24-2012, 10:05 AM
  2. Bipolar disorder may be linked to 'body clock'
    By cougarnurse in forum Psych Nursing
    Replies: 0
    Last Post: 11-28-2009, 09:04 AM
  3. 'Sudden death' after arrest = new syndrome?
    By cougarnurse in forum Nursing News
    Replies: 0
    Last Post: 09-02-2008, 07:07 PM
  4. Study links preterm birth and infections
    By cougarnurse in forum OB-Gyne Forum
    Replies: 0
    Last Post: 08-27-2008, 04:33 PM
  5. Study links preemies and long term risks
    By cougarnurse in forum Nursing News
    Replies: 0
    Last Post: 03-25-2008, 10:27 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •