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Old 04-26-2008, 09:52 AM   #1 (permalink)
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Enoxaparin affected by Heparin contaminant

Saw this on Medscape, and thought it important:

April 25, 2008 (Paris, France) - The contaminant found in heparin has now also been identified in some batches of the low-molecular-weight heparin enoxaparin (Lovenox/Clexane), the manufacturer, Sanofi-Aventis, has reported. But no increase in adverse reactions has been seen with the product.
The company told heartwire that it has put in place screening tests for the contaminant, oversulfated chondroitin sulfate, which has been detected "in very small concentrations" in a few batches. Sanofi-Aventis spokesperson Salah Mahyaoui said that the company has alerted all worldwide health authorities of its findings and the batches affected "as a precautionary measure," and different countries have taken different actions.
So far, three countries--Australia, Sweden, and Italy--have requested the recall of the enoxaparin lots containing the contaminant. Other countries, including France, Belgium, and Spain, have advised that the product should be given only by subcutaneous injection, as the adverse reactions seen with contaminated heparin in the US and Germany have been associated with bolus intravenous use. Other countries have said that no action is necessary at this time, as there have been no adverse reactions reported and the contaminant is present in such low concentrations, Mahyaoui added.
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Old 05-02-2008, 12:07 PM   #2 (permalink)
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Re: Enoxaparin affected by Heparin contaminant

Before it hit the News, we were affected here in my Dialysis Clinic. Now we are getting loads of questions. Thank God we didn't have any issues with the Heparin/Lovenox in our area.
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